angiotensin II
angiotensin II
CAS: 4474-91-3
Molecular Formula: C50H71N13O12
angiotensin II - Names and Identifiers
| Name | angiotensin II |
| Synonyms | DRVYIHPF angiotensin II [ILE5]-ANGIOTENSIN 2 Angiotensin Ii, Human ANGIOTENSIN II, HUMAN HYPERTENSION II HUMAN L-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH 2CH3CHOOH H2O FLUORESCEIN-NHCS-NH-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH |
| CAS | 4474-91-3 |
| EINECS | 2017-001-1 |
| InChI | InChI=1/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 |
| InChIKey | CZGUSIXMZVURDU-JZXHSEFVSA-N |
angiotensin II - Physico-chemical Properties
| Molecular Formula | C50H71N13O12 |
| Molar Mass | 1046.2 |
| Density | 1.1257 (rough estimate) |
| Boling Point | 809.08°C (rough estimate) |
| Water Solubility | Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml). |
| Solubility | Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml). |
| Appearance | Powder |
| Color | orange |
| pKa | pK1: 10.37 (25°C) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Sensitive | Thermal sensitivity |
| Refractive Index | 1.6700 (estimate) |
| Physical and Chemical Properties | White freeze-dried powder; Soluble in water, soluble in methanol, ethanol and propylene glycol, insoluble in ether and chloroform; PH value of 5-8 in aqueous solution; Stable in neutral solution, in case of strong acid, when strong base is easy to hydrolyze; Amino acid sequence: aspartyl, arginyl, beratyl, tyrosyl, isobalatyl, aminoacyl, prolyl, phenylalanine. |
| Use | A peptide involved in the regulation of blood pressure |
| In vitro study | Most of the known actions of Angiotensin II (Ang II) are mediated by AT 1 receptors, the AT 2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT 1 ). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT 1 and AT 2 ). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors. |
| In vivo study | To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption. |
angiotensin II - Risk and Safety
| WGK Germany | 3 |
| RTECS | BW2165000 |
angiotensin II - Reference
| Reference Show more | 1. Zheng Wei Chang Hulin Navy song Xiaoxue du Lixue. Effect of Ang Ⅱ on activation and proliferation of hepatic stellate cell LX2 by activating Notch1/Sox2 pathway [J]. Chinese Journal of Cell and stem cells (Electronic Edition) 2018 8(03):156-160. 2. Ruanxu, Yang Min, Xu, Zhongru et al. Protective effect of Salvia miltiorrhiza injection on Ang Ⅱ induced NRK-52E cell injury [J]. Chinese patent medicine 2018 040(005):1170-1173. 3. Liu Xiaoyu, Cheng Saibo, Xu Yiling, He Peikun, Gu Minhua, Zhou Fenghua, Jia Yuhua. Based on ACE2-Ang(1-7)-Mas axis to explore the mechanism of Dingxin Prescription No. 3 to improve the function of human umbilical vein endothelial cells [J]. Chinese new medicines and clinical pharmacology, 2019,30(03):301-307. 4. Kuang Cong, Jia Junqiang, Wu qionying, et al. Effect of ultrasonic-ionic liquid treatment on enzymatic hydrolysis kinetics and antioxidant activity of whey protein [J]. Food Science, 2017, 29 (23):32-38. 5. Niepe, Meng Fanjing, Zhang Jinguo, Wei Xiqing. Astragaloside Ⅳ inhibits apoptosis of H9c2 cells induced by angiotensin Ⅱ [J]. Chinese Journal of pathophysiology, 2019,35(11):1942-1950. 6. Pie, Pei, et al.." Oxidative medicine and cellular longevity 2019 (2019).https://doi.org/10.1155/2019/4625 7. [IF=4.868] Nie Pei et al."Astragaloside IV Exerts a Myocardial Protective Effect against Cardiac Hypertrophy in Rats, Partially via Activating the Nrf2/HO-1 Signaling Pathway."Oxid Med Cell Longev. 2019;2019:4625912 8. [IF=3.943] Kaiyong Yang et al."Angiotensin II contributes to intratumoral immunosuppression via induction of PD-L1 expression in non-small cell lung carcinoma."Int Immunopharmacol. 2020 Jul;84:106507 9. [IF=2.629] Mo Jiajia et al."Liquiritin Attenuates Angiotensin II-Induced Cardiomyocyte Hypertrophy via ATE1/TAK1-JNK1/2 Pathway."Evid-Based Compl Alt. 2022;2022:7861338 |
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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